Synthetic Peptides

Granite Biologicals provides custom peptides for the production of antibodies
and labelled peptides for assay development. We also offer high-throughput
screening and cGMP peptides for use in clinical trial experiments.

 

Additionally, we have the capacity and expertise to synthesize a large and
diverse range of peptides. This is done with dedication to providing high
quality products with fast turnaround times.

 

Capable of delivering research peptides in the milligram to kilogram range,
we use our own novel technologies to facilitate more efficient peptide synthesis
synthesis resulting in cleaner peptides.  

 

This allows us to approach peptides up to 130 amino acids in length confidently
and complete the projects in realistic timeframes.

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Using our experience and industry-leading synthetic strategies, we prevail over
difficult stretches in the peptide sequence, tackling synthesis problems before they occur.

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Peptide Capabilities 

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Our instrumentation capabilities include continuous flow and batch peptide synthesizers, which allow us to synthesize hundreds of peptides per week.

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Continuous Flow Synthesis

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This method of peptide synthesis allows the peptide to assemble more efficiently and faster by removing excess reagents from the reaction chamber.  This process is particularly suited to the synthesis of long and synthetically challenging peptides, as it allows good swelling properties of the peptide resin to be maintained during the synthesis process.  As a result, peptide aggregation/ truncation is lowered, giving rise to higher purity peptides.

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Batchwise Synthesis

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This method of peptide synthesis is compatible with Fmoc/ tBu and Boc/ Bzl methods, as well as a wide range of solid supports for peptide synthesis.  This process is particularly suited to producing large peptide libraries in shortened turnaround times.  Due to the processes involved in this type of synthesis, the resulting peptide quality is lower than that obtained from continuous flow synthesis.

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Manual Synthesis

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For complicated peptide sequences, we can adopt a manual synthesis approach.  We have successfully made glycopeptides, labelled peptides and branched peptides as well as others, using manual synthesis.  Manual synthesis is more flexible than automated methods and usually results in a better crude peptide when compared to machine synthesis.  At Granite Biologicals, we are able to utilize both methods and therefore are able to offer you advantages in automatic (cost and speed) and manual synthesis (complex peptides).  We are also able to offer solution-phase synthesis.

 

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